In association with


STUDY: Evidence of Effectiveness in prevention of:

  • Acute diarrhea
  • Antibiotic-induced diarrhea
  • Cow-milk induced allergy in infants
  • Respiratory infections in children
  • IBS and other inflammatory bowel diseases

STUDY: Evidence of Effectiveness in prevention of:

  • Acute diarrhea
  • Pouchitis and atopic eczema in children
  • Genitourinary (GI) infections

The researchers reviewed more than 100 articles and studies published in various medical and scientific journals. They selected 45 studies and reviews based on the criteria that included randomized, blinded studies, and unbiased articles.

STUDY: Benefit of Probiotic is strain-specific

As consumers increasingly take to probiotics for health benefits, it is important to understand that the benefit is strain-specific as is the disease-specific efficacy.

Not all probiotics are equally effective.

The authors of the study conducted a systematic review of the literature (1970–2017) which included 228 trials involving probiotics and found “evidence for both strain specificity and disease specificity for the efficacy of specific probiotic strains.”

The found significant efficacy evidence 7 (70%) of probiotic strain(s) among four preventive indications and 11 (65%) probiotic strain(s) among five treatment indications.

Citing individual studies, they reported that strain-specific efficacy for preventing adult antibiotic-associated diarrhea was clearly demonstrated within the Lactobacillus species [[e.g., by the mixture of Lactobacillus acidophilus CL1285, Lactobacillus caseiLBC80R, and Lactobacillus rhamnosus CLR2 (Bio-K+®), by L. casei DN114001 (Actimel®) and by Lactobacillus reuteri 55730], while other Lactobacillus strains did not show efficacy. Significant disease-specific variations in efficacy was demonstrated by L. rhamnosus GG and Saccharomyces boulardiiCNCM I-745, as well as other probiotic strains.

“The clinical relevance of these findings indicates that health-care providers need to take these two factors into consideration when recommending the appropriate probiotic for their patient,” they said.

The scientists concluded that while the clinical choice of the appropriate probiotic for each patient is challenging, there however “is strong evidence for the efficacy of specific probiotics for several diseases (AAD, CDI, IBD, IBS, TD, acute pediatric diarrhea, and for H. pyloriinfections).